Nexium Acid Reflux – The Lavender Capsule
May 12th, 2014
Nexium (esomeprazole) is a new word in the treatment of acid-related diseases of the gastrointestinal tract.
Despite the huge number of publications on proton pump inhibitors (PPIs), the interest in it among doctors and patients is not reduced. This is due to high relevance of acid diseases of the upper gastrointestinal tract, as well as the high efficiency of this group of drugs to combat them. Among the drugs the basic treatment of these diseases, which include M-anticholinergics, H2-receptor blockers and proton pump inhibitors, the latest rightfully occupy a leading position.
Following oral administration of esomeprazole is absorbed in the small intestine and transported to parietal cells of the gastric mucosa, where by diffusion it accumulates within the lumen of the secretory tubules. There, under the influence of the acidic environment there is a transition to the active form of esomeprazole – sulfenamide – allowing its binding with the thiol groups of cysteine in the proton pump and the inhibition of this enzyme. The result is the reduction of acid secretion in the stomach.
Esomeprazole has a unique delivery system of the active substance – MUPS (Multiple Unit Pellet System). This is a new form that provides maximum protection for the active substance and at the same time its quick delivery to the site of absorption in the duodenum. CI tablet consists of one thousand microcapsules with the active substance, so it rapidly dissolves in the stomach and without delay PPI enters the duodenum for absorption into the bloodstream.
Currently, data on the use of esomeprazole in pregnancy is limited. In animal studies, there were not revealed any direct or indirect adverse effects of Nexium on the development of the embryo or fetus. Introduction racemic drug also did not have any adverse effects on animals during pregnancy, childbirth and during postnatal development.
Nexium Australia should only be prescribed during pregnancy only if the case when the expected benefit to the mother outweighs the potential risk to the fetus.
There are no data on the use of the drug in women during lactation. It is not known whether esomeprazole with breast milk, so should not be prescribed Nexium during lactation.
Categories: Nexium